Open AccessEffect of Amine Oxide Zwitterionic Surfactant on Characteristics of Liposome
Author(s) -
DaHee Mo,
SuMin Lee,
JuYeon Lee,
DongSung Han,
JongChoo Lim
Publication year - 2016
Publication title -
applied chemistry for engineering
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.144
H-Index - 11
eISSN - 2288-4505
pISSN - 1225-0112
DOI - 10.14478/ace.2016.1035
Subject(s) - amine oxide , chemistry , pulmonary surfactant , isoelectric point , zeta potential , liposome , critical micelle concentration , amine gas treating , micelle , thermodynamics of micellization , cationic polymerization , inorganic chemistry , organic chemistry , aqueous solution , chemical engineering , nanoparticle , biochemistry , engineering , enzyme
In this study, zwitterionic surfactants were added to liposome systems at different pH conditions to understand the effect of surfactants on liposome characteristics. For this purpose, amine oxide surfactants having different hydrocarbon chain lengths were synthesized and the structure of the resulting product was elucidated by using H NMR, C NMR, and FT-IR. In addition, the physical properties of newly synthesized surfactants such as critical micelle concentration (CMC), surface tension and isoelectric point were measured. The stability characteristics of liposome systems including average particle sizes and zeta potentials were measured by varying pH and hydrocarbon chain lengths of an amine oxide surfactant. Effects of the pH and hydrocarbon chain length of an amine oxide surfactant on fluidity of a liposome membrane were also examined by measuring the deformability and the binding degree between the surfactant and liposome.
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