English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Objective To evaluate the effects of Living-High Training-Low on HIF-1α transcriptional regulatory factors MAPKs mRNA in gastrocnemius of Rats.&#x0D;Methods After adaptive training, 40 8-weeks-old male SD rats were divided into living-low quiet control group (LC), living-low training-low group (LoLo), living-high quiet control group (HC), living-high training-low group (HiLo). All living-high groups stayed in the environment with 13.6% oxygen concentration, about altitude of 3500 m, for 12h/day. All training groups underwent treadmill training with 35m/min for 1hour/day, 5days/week. 4 weeks later, the gastrocnemius was sampled 24 hours after the last training. The ERK, p38MAPK, JNK and HIF-1α mRNA genes expressions in gastrocnemius were measured by real-time quantitative PCR.&#x0D;Results The gastrocnemius ERK mRNA of HiLo group was significantly higher than LC (P 0.05). The JNK and HIF-1α mRNA of HiLo group were significantly higher than other groups (P&lt;0.01).&#x0D;Conclusions Living-High Training-Low significantly raise ERK、p38MAPK、JNK and HIF-1α gene expression in gastrocnemius of Rats. ERK, p38MAPK and JNK may be one of the transcription factors regulating HIF-1α mRNA expression in Living-High Training-Low in gastrocnemius of Rats.

PO-165 Effects of Living-High Training-Low on HIF-1α Transcriptional Regulatory Factors MAPKs mRNA in Gastrocnemius of Rats