English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Objective: The improvement of cardiorespiratory fitness (CRF) is known as an effective strategy for prevention cardiovascular risk. Myocardial aerobic oxidation which control by the signal way of adenosine monophosphate -activated protein kinase (AMPK)- peroxisome proliferators γ activated receptor coativator-1-α (PGC-1α)  is the key for CRF. Previous studies only discuss the effect of the Moderate-Intensity Continuous Training (MICT) and High Intensive Interval Training (HIIT) on the signal way of AMPK- PGC-1α in skeletal muscle but not in the myocardium. The aim of this study was to compare the effects of 10 weeks HIIT and MICT on the expression of AMPK and PGC-1α in the myocardium of wistar male rats. Methods: Wistar male rats (n=30) aged 6 weeks were randomly divided into HIIT or MICT or control (CON) group. The training groups ran on a treadmill 5 days/week for 10 weeks. HIIT group ran six times 3 minutes (0° slope) 90% of Vmax separated by 3 minutes 50% of Vmax and MICT group ran for 50min (0° slope) at 60–70% of maximal speed (Vmax). The expression of AMPK and PGC-1α were assessed by Western Blotting. Results: After 10 weeks training, HIIT and MICT both increased the AMPK and PGC-1α expression compared with the CON group. Compared with the MICT group, the expression of AMPK and PGC-1α were significantly higher than the HIIT group (p<0.05). AMPK in MICT group were significant increased 1.16 times, and in HIIT group were significant increased 1.28 times to CON (P<0.05). PGC-1α level of HIIT was significant increased to 1.32 times to CON and also significant increased to 1.15 times to Group M (P<0.05); PGC-1α level of MICT was significant increased to 1.15 times to CON. ConclusionHIIT seems to improve myocardial AMPK and PGC-1α more efficiently than MICT in rats after 10 weeks training.

OR-005 Effects of HIITand MICT for 10 weeks on myocardial AMPK and PGC-1α in rats