Nuclear Organization and Epigenetic Regulation of Olfactory Receptor (OR) Genes

13 Chapter 1: Introduction 15 Anatomical features of the olfactory system in vertebrates 16 Cell lineages of main olfactory epithelium: neurogenesis in the MOE 18 A large family of odorant receptors 26 Chromosomal distribution and genomic features of OR genes 27 Mutually exclusive OR gene expression – monogenic and monoallelic 28 Deterministic regulatory models in OR expression 29 Zonal expression patterns in the MOE 30 Cis regulatory elements in OR promoters 31 Transcription factors and enzymes shaping zonal expression patterns 34 Onset of odorant receptor expression – temporal patterning 37 Stochastic regulatory models in OR singularity 38