Neuronal Activity-Dependent Regulation of MicroRNAs | Zendy

Su-Eon Sim | Zendy; Joseph Bakes | Zendy; BongKiun Kaang | Zendy

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Neuronal Activity-Dependent Regulation of MicroRNAs

Author(s) -

Su-Eon Sim,

Joseph Bakes,

BongKiun Kaang

Publication year - 2014

Publication title -

molecules and cells

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.665

H-Index - 79

eISSN - 0219-1032

pISSN - 1016-8478

DOI - 10.14348/molcells.2014.0132

Subject(s) - microrna , gene silencing , biology , premovement neuronal activity , regulation of gene expression , synapse , synaptic plasticity , neuroplasticity , neuroscience , gene expression , gene , microbiology and biotechnology , genetics , receptor

MicroRNAs are non-coding short (~23 nucleotides) RNAs that mediate post-transcriptional regulation through sequence-specific gene silencing. The role of miRNAs in neuronal development, synapse formation and synaptic plasticity has been highlighted. However, the role of neuronal activity on miRNA regulation has been less focused. Neuronal activity-dependent regulation of miRNA may fine-tune gene expression in response to synaptic plasticity and memory formation. Here, we provide an overview of miRNA regulation by neuronal activity including high-throughput screening studies. We also discuss the possible molecular mechanisms of activity-dependent induction and turnover of miRNAs.

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