Predictors of the effectiveness of the treatment of symptoms of the chronic painful form of diabetic polyneuropathy with the use of alpha-lipoic acid | Zendy

О Е Хуторная | Zendy; Вадим Борисович Бреговский | Zendy; A G Demina | Zendy; И. А. Карпова | Zendy; Elena Grineva | Zendy

Open Access

Predictors of the effectiveness of the treatment of symptoms of the chronic painful form of diabetic polyneuropathy with the use of alpha-lipoic acid

Author(s) -

О Е Хуторная,

Вадим Борисович Бреговский,

A G Demina,

И. А. Карпова,

Elena Grineva

Publication year - 2013

Publication title -

problems of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.124

H-Index - 5

eISSN - 2308-1430

pISSN - 0375-9660

DOI - 10.14341/probl201359114-17

Subject(s) - medicine , sensation , allodynia , polyneuropathy , hyperalgesia , chronic pain , anesthesia , neuralgia , burning sensation , lipoic acid , neuropathic pain , physical therapy , surgery , psychology , nociception , neuroscience , antioxidant , receptor , biochemistry , chemistry

This work was designed to study dynamics of the symptoms of chronic painful form of diabetic polyneuropathy under the influence of the short-term treatment with alpha-lipoic acid (ALA) and to identify the predictors of its effectiveness. Lipoic acid was administered by means of 10 infusions dosed 600 mg each. ALA had the most pronounced therapeutic effect on convulsions, gnawing pain, the feeling of "pins and needles", burning sensation, and neuralgia. Dynamics of allodynia, hyperalgesia, and negative symptoms was insignificant. The predictors of low effectiveness of ALA were high intensity of painful and other sensations underlain by central pain maintaining mechanisms.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research