The choice of oral hypoglycemic agents: the current view of the problem

The advantages of combined therapy of diabetes mellitus (DM) with the use of fixed combinations, such as glybenclamide plus metformin are discussed. The principal ones are the lowered dose of each component without the loss of therapeutic efficacy, marked reduction in the frequency of adverse reactions affecting the gastrointestinal tract, minimal risk of hypoglycemic episodes, etc. The fixed combination of glybenclamide plus metformin makes it possible to prescribe flexible dosage regimes, enhanves compliance, ensures psychological comfort, and improves the quality of life.