Disturbances in the hemostatic system of patients with endogenous hypercorticism and metabolic syndrome

Long-standing hypercortisolemia is accompanied by multiple defects of metabolic regulation. Glucocorticoids are known to affect not only metabolic processes but also the vascular wall directly influencing its remodeling and angiogenesis. Syndrome of endogenous hypercorticism is characterized by various disturbances in the hemostatic system and a tendency toward the development of hypercoagulation. Altered metabolic and hemostatic parameters in the active phase of the disease persist during a long time after the achievement of remission. It accounts for the high risk of atherosclerosis, atherothrombosis, and thromboembolic complications which necessitates correction with medicinal preparations throughout the follow-up period. According to foreign authors, thromboembolic complications are the main cause of mortality among the patients with this clinical condition and occur 4 times as frequently as in the general population.