Elemental composition of the bone tissue in mice treated with a combination of thyroxin and diazepam in a model carcinogenic system | Zendy

Anvar Abduvaliev | Zendy; M A Ismaĭilova | Zendy; М С Гильдиева | Zendy; Saatov Ts | Zendy

Open Access

Elemental composition of the bone tissue in mice treated with a combination of thyroxin and diazepam in a model carcinogenic system

Author(s) -

Anvar Abduvaliev,

M A Ismaĭilova,

М С Гильдиева,

Saatov Ts

Publication year - 2010

Publication title -

problems of endocrinology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.124

H-Index - 5

eISSN - 2308-1430

pISSN - 0375-9660

DOI - 10.14341/probl201056331-33

Subject(s) - diazepam , receptor , carcinogen , chemistry , medicine , endocrinology , bone tissue , pharmacology , biology , biochemistry , anatomy

It is shown that combined treatment with thyroxin and diazepam permits to avoid negative effect of either drug on the bone tissue. Mutual regulation of thyroxin and diazepam activities is mediated through their competitive binding to common receptors. It is hypothesized that the key factor in this process is steric availability of the receptor; in other words, close localization of thyroxin and diazepam targets may interfere with simultaneous activation of receptors by the two ligands and account for the effects of their combined administration described in the present work.

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