The Apoptosis of Blood Neutrophils and Immunoregulatories Cytokines in Patients with Autoimmune Thyropaties | Zendy

О. И. Уразова | Zendy; E B Kravez | Zendy; В. В. Новицкий | Zendy; В. Н. Кузнецова | Zendy; А. В. Рогалева | Zendy

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The Apoptosis of Blood Neutrophils and Immunoregulatories Cytokines in Patients with Autoimmune Thyropaties

Author(s) -

О. И. Уразова,

E B Kravez,

В. В. Новицкий,

В. Н. Кузнецова,

А. В. Рогалева

Publication year - 2007

Publication title -

clinical and experimental thyroidology

Language(s) - English

Resource type - Journals

eISSN - 2310-3787

pISSN - 1995-5472

DOI - 10.14341/ket20073449-53

Subject(s) - medicine , autoimmune thyroiditis , immunology , apoptosis , autoimmune disease , euthyroid , cytokine , thyroiditis , graves' disease , disease , thyroid , antibody , biochemistry , chemistry

The object of the research was to study the apoptosis of blood neutrophils and amount of immunoregulatory cytokines (TNF-α, IL-8, IL-4) in patients at the age from 19 to 60 years. 52 euthyroid patients (11 men and 41 women) with autoimmune thyroiditis (AIT) and 15 patients (5 men and 10 women) with Graves’ disease (GD) with thyrotoxicosis of various severity were examined. It was shown, that current AIT and GD is characterized by an increase of neutrophils readiness for apoptosis against a background of blood cytokine profile with reflects neutrophils active involving in the disease immunopathogenesis of autoimmune thyropaties.

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