Mobilization of endothelial progenitor cells after endovascular interventions in patients with type 2 diabetes mellitus

Aim. To investigate the mobilisation of endothelial progenitor cells (EPC) in patients with type 2 diabetes mellitus (T2DM) after endovascular interventions for coronary and peripheral arteries. Materials and Methods. The levels of EPC in peripheral blood were determined by flow cytometry in 42 patients prior to endovascular intervention and 2?4 days after surgery. EPC were defined as CD34+ VEGFR2+ CD45- and CD34+ CD133+CD45- cells. Twenty-three patients with T2DM were included in group 1, and 19 patients without metabolic disorders were included in group 2. Results. The levels of EPC in the peripheral blood of patients with T2DM before and after endovascular interventions were not significantly different. In the subgroup of patients without TDM2, the levels of CD34+VEGFR2 +CD45- cells increased after surgery to 55,5% (p 1c  ?7,5%, the levels of CD34+VEGFR2+CD45- cells increased to 46,6% (p=0,01), and the levels of CD34+CD133+CD45- cells increased to 40,3 % (p=0,006) compared with the subgroup of patients with T2DM and with HbA 1c  levels of?7,5%. Conclusion. The patients with T2DM displayed alterations in EPC mobilisation after endovascular interventions. In addition, the EPC level changes were dependent on glycaemic control. Thus, in the subgroup of patients with T2DM and with good glycaemic control (HbA 1c  ?7,5%), the EPC levels were significantly higher after endovascular interventions.