Elevated a-Fetoprotein in the Absence of Carcinoma Caused by Relapse of Hepatitis C Viral Infection after Liver Transplantation | Zendy

Tomomi Kogiso | Zendy; Takaomi Sagawa | Zendy; Yoshihito Kotera | Zendy; Hiroto Egawa | Zendy; Masakazu Yamamoto | Zendy; Katsutoshi Tokushige | Zendy

Open Access

Elevated a-Fetoprotein in the Absence of Carcinoma Caused by Relapse of Hepatitis C Viral Infection after Liver Transplantation

Author(s) -

Tomomi Kogiso,

Takaomi Sagawa,

Yoshihito Kotera,

Hiroto Egawa,

Masakazu Yamamoto,

Katsutoshi Tokushige

Publication year - 2018

Publication title -

acg case reports journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.112

H-Index - 4

ISSN - 2326-3253

DOI - 10.14309/crj.2018.103

Subject(s) - hepatocellular carcinoma , medicine , liver transplantation , cirrhosis , clearance , hepatitis c , hepatitis c virus , titer , gastroenterology , interferon , transplantation , alpha fetoprotein , virology , virus , urology

We report a rare case of marked elevation of α-fetoprotein in the absence of hepatocellular carcinoma caused by a relapse of hepatitis C virus (HCV) infection. A 58-year-old man underwent liver transplantation to treat hepatocellular carcinoma caused by HCV-related liver cirrhosis. The HCV was of genotype 2a, and the ribonucleic acid titer was >8.0 log IU/mL. Direct-acting antiviral drugs were prescribed for 12 weeks; however, the HCV infection relapsed after treatment had ended, and α-fetoprotein levels increased to 8,981 ng/mL. Imaging did not reveal any malignancies. The patient initiated interferon therapy, at which time AFP levels decreased, and the HCV was successfully cleared.

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