Resolution of Diffuse Intrahepatic Biliary Strictures after Chemotherapy for Metastatic Ovarian Cancer | Zendy

Daniel Lew | Zendy; Vinay Sundaram | Zendy; Brad Barrows | Zendy; Simon K. Lo | Zendy; Srinivas Gaddam | Zendy

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Resolution of Diffuse Intrahepatic Biliary Strictures after Chemotherapy for Metastatic Ovarian Cancer

Author(s) -

Daniel Lew,

Vinay Sundaram,

Brad Barrows,

Simon K. Lo,

Srinivas Gaddam

Publication year - 2017

Publication title -

acg case reports journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.112

H-Index - 4

ISSN - 2326-3253

DOI - 10.14309/crj.2017.77

Subject(s) - medicine , endoscopic retrograde cholangiopancreatography , chemotherapy , jaundice , intrahepatic cholangiocarcinoma , complication , metastatic carcinoma , ovarian cancer , liver biopsy , cancer , intrahepatic bile ducts , biopsy , gastroenterology , pathology , radiology , carcinoma , bile duct , pancreatitis

Sclerosing cholangitis and cholestatic jaundice secondary to metastatic disease is a rare complication. We report a rare case of secondary sclerosing cholangitis (SSC) due to lymphatic spread from ovarian cancer with complete resolution after chemotherapy. The diagnosis of SSC from metastatic ovarian cancer was clinically challenging, as endoscopic retrograde cholangiopancreatography revealed irregular hepatic ducts consistent with sclerosing cholangitis, but it did not identify any malignant cells. The final diagnosis was made with liver biopsy revealing high-grade metastatic Mullerian carcinoma. The patient responded well to chemotherapy and is in remission. A timely diagnosis is important and can lead to complete resolution of the disease.

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