Novel Application of Extracorporeal Photopheresis as Treatment of Graft-versus-Host Disease Following Liver Transplantation | Zendy

Timothy J. Brown | Zendy; Cathy Gentry | Zendy; Suntrea T.G. Hammer | Zendy; Christine Hwang | Zendy; Madhuri Vusirikala | Zendy; Prapti A. Patel | Zendy; Karén Matevosyan | Zendy; Shannan R. Tujios | Zendy; Arjmand Mufti | Zendy; Robert H. Collins | Zendy

Open Access

Novel Application of Extracorporeal Photopheresis as Treatment of Graft-versus-Host Disease Following Liver Transplantation

Author(s) -

Timothy J. Brown,

Cathy Gentry,

Suntrea T.G. Hammer,

Christine Hwang,

Madhuri Vusirikala,

Prapti A. Patel,

Karén Matevosyan,

Shannan R. Tujios,

Arjmand Mufti,

Robert H. Collins

Publication year - 2017

Publication title -

acg case reports journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.112

H-Index - 4

ISSN - 2326-3253

DOI - 10.14309/crj.2017.48

Subject(s) - medicine , photopheresis , extracorporeal photopheresis , pancytopenia , rash , immunosuppression , diarrhea , graft versus host disease , liver transplantation , hepatocellular carcinoma , transplantation , plasmapheresis , gastroenterology , surgery , dermatology , immunology , lymphoma , bone marrow , antibody

A 48-year-old man with hepatitis C virus (HCV) cirrhosis complicated by hepatocellular carcinoma underwent liver transplantation. His course was complicated by fever, diarrhea, abdominal pain, and pancytopenia. He developed a diffuse erythematous rash, which progressed to erythroderma. Biopsies of the colon and skin were consistent with acute graft-versus-host disease. Donor-derived lymphocytes were present in the peripheral blood. The patient was treated with corticosteroids and cyclosporine; however, he had minimal response to intensive immunosuppressive therapy. Extracorporeal photopheresis was initiated as a salvage therapy. He had a dramatic response, and his rash, diarrhea, and pancytopenia resolved. He is maintained on minimal immunosuppression 24 months later.

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