Hereditary Persistence of Alpha-Fetoprotein Is Associated with the —119G>A Polymorphism in AFP Gene | Zendy

Neha Deshpande | Zendy; Radhika Chavan | Zendy; Govardhan Bale | Zendy; Urmila Steffie Avanthi | Zendy; Mohsin Aslam | Zendy; Mohan Ramchandani | Zendy; D. Nageshwar Reddy | Zendy; Vishnubhotla Ravikanth | Zendy

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Hereditary Persistence of Alpha-Fetoprotein Is Associated with the —119G>A Polymorphism in AFP Gene

Author(s) -

Neha Deshpande,

Radhika Chavan,

Govardhan Bale,

Urmila Steffie Avanthi,

Mohsin Aslam,

Mohan Ramchandani,

D. Nageshwar Reddy,

Vishnubhotla Ravikanth

Publication year - 2017

Publication title -

acg case reports journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.112

H-Index - 4

ISSN - 2326-3253

DOI - 10.14309/crj.2017.33

Subject(s) - medicine , penetrance , alpha fetoprotein , persistence (discontinuity) , gene , fetus , genetics , gastroenterology , bioinformatics , pregnancy , biology , phenotype , geotechnical engineering , engineering , hepatocellular carcinoma

Alpha-fetoprotein (AFP) is a glycoprotein that is produced by the liver and yolk sac during fetal development. Its levels are usually raised in malignant conditions. Hereditary persistence of AFP (HPAFP) is a rare benign condition with elevated levels of AFP. It is inherited in a dominant mode with complete penetrance and is usually not associated with any clinical disability. We report two individuals with elevated levels of AFP harboring the -119G>A polymorphism in the gene. A genetic screening to rule out variants in the gene is advised in cases with unexplained persistent AFP levels to avoid inappropriate treatment and surgical options.

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