Hepatitis C Virus-Associated Aortitis Caused by Type I Cryoglobulins | Zendy

Adrienne Lenhart | Zendy; Alireza Meighani | Zendy; Mona Hassan | Zendy; Stuart Gordon | Zendy

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Hepatitis C Virus-Associated Aortitis Caused by Type I Cryoglobulins

Author(s) -

Adrienne Lenhart,

Alireza Meighani,

Mona Hassan,

Stuart Gordon

Publication year - 2017

Publication title -

acg case reports journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.112

H-Index - 4

ISSN - 2326-3253

DOI - 10.14309/crj.2017.114

Subject(s) - medicine , cryoglobulins , cryoglobulinemia , aortitis , vasculitis , hepatitis c virus , pathology , hepatitis c , dermatology , immunology , gastroenterology , disease , virus , aorta , antibody

Chronic hepatitis C virus infection (HCV) can present with cryoglobulinemic vasculitis, which is primarily associated with type II/III cryoglobulins. Type I cryoglobulins are usually seen in lymphoproliferative disease, and large vessel involvement with this type of vasculitis is rare. A 70-year-old man with chronic HCV presented with abdominal pain, leukocytosis, and rash. Computed tomography angiography showed thickening of the abdominal aorta consistent with large-vessel vasculitis. He was found to have type I cryoglobulinemia and was treated with corticosteroids and ledipasvir/sofosbuvir with rapid resolution of his aortitis. This case emphasizes the need to recognize HCV as a potential etiology of large-vessel vasculitis.

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