Common Variable Immunodeficiency with Several Gastrointestinal Manifestations | Zendy

Catarina AtalaiaMartins | Zendy; Sandra Barbeiro | Zendy; Pedro Marcos | Zendy; Isabel Cotrim | Zendy; M. Helena Vasconcelos | Zendy

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Common Variable Immunodeficiency with Several Gastrointestinal Manifestations

Author(s) -

Catarina AtalaiaMartins,

Sandra Barbeiro,

Pedro Marcos,

Isabel Cotrim,

M. Helena Vasconcelos

Publication year - 2017

Publication title -

acg case reports journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.112

H-Index - 4

ISSN - 2326-3253

DOI - 10.14309/crj.2017.106

Subject(s) - common variable immunodeficiency , medicine , enteropathy , malignancy , sprue , villous atrophy , gastroenterology , dysplasia , immunodeficiency , cancer , hypogammaglobulinemia , differential diagnosis , disease , pathology , immunology , immune system , coeliac disease , mold , antibody , biology , genetics

Common variable immunodeficiency (CVID) is an immunodeficiency disorder with a high incidence of gastrointestinal (GI) manifestations and an increased risk of gastric malignancy. We report a case of a CVID with mild anemia presenting with multiple GI manifestations: gastric low-grade dysplasia (LGD), enteropathy with villous atrophy, refractory Giardia infection, nodular lymphoid hyperplasia, and inflammatory bowel-like disease. The differential diagnosis with celiac sprue could be challenging because of CVID enteropathy with villous flattening. Gastric LGD in a patient with an increased risk for gastric malignancy makes the appropriate surveillance of gastric cancer in CVID challenging.

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