
The Intersection of Cultural Characteristics and Genetics on the Prevalence of Delayed Sleep Phase Syndrome in Brazilian and Japanese Adults
Author(s) -
Abram Estafanous,
Karim Sedky
Publication year - 2020
Publication title -
journal of sleep and sleep disorder research
Language(s) - English
Resource type - Journals
ISSN - 2574-4518
DOI - 10.14302/issn.2574-4518.jsdr-20-3161
Subject(s) - circadian rhythm , circadian clock , gene , clock , genetics , delayed sleep phase , biology , sleep (system call) , sleep disorder , neuroscience , cognition , computer science , operating system
Delayed sleep phase syndrome (DSPS) is a circadian rhythm disorder where individuals experience difficulty modifying the time they go to sleep and wake up in response to environmental changes. The circadian rhythm itself is regulated by a variety of clock genes, and various other genes (e.g., AA-NAT gene, CKIϵ gene) code for proteins that regulate clock genes. Various polymorphisms of the clock gene influencers have been shown to increase susceptibility to DSPS. This paper seeks to examine how certain cultural characteristics (e.g., napping, timing of meals, exposure to artificial light) and the presence of the AA-NAT gene (G619A polymorphism) and the CKIϵ gene (S408N polymorphism) influence the prevalence of DSPS amongst Japanese and Brazilian populations.
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