STUDY TO ESTABLISH CORRELATION BETWEEN VITAMIN D, PTH AND BMD IN TYPE 2 DIABETIC PATIENTS

BACKGROUND Type 2 Diabetes Mellitus still remains one of the leading causes of morbidity and mortality. Diabetic patients are prone to osteoporosis. The development of osteoporosis in diabetes is also promoted by the coexistence of chronic microvascular complications of diabetes, which also affect the bone marrow blood vessels. Diabetic osteopathy is a significant comorbidity of diabetes and is characterised by microarchitectural changes that decrease bone quality and reduction of bone strength leading to an increased risk of bone fracture in diabetes. There is high prevalence of vitamin D deficiency and hyperparathyroidism in uncontrolled diabetic patients, which further leads to osteopenia or osteoporosis. Aims and ObjectivesTo establish correlation between vitamin D, PTH and BMD with diabetic control and complications of type 2 diabetic patients. MATERIALS AND METHODS An observational study was conducted in Medicine Department of Nehru Hospital, BRD Medical College, Gorakhpur. Data entry and analysis was done by IBM SPSS Version 22 using Fisher exact test and Pearson Chi-square test. A total of 100 clinically diagnosed patients of type-2 diabetes mellitus were selected for the study. Duration of study was 1 year (Jan 2017 to Dec 2017). All the patients were subjected to detailed clinical history, examination and relevant investigations like HbA1c, BMD, vitamin D, PTH, urine microscopy, fundus etc. were done in all patients.