The Effects of Peroxiredoxin 6 Gene rs41055489 Variation on Oxidative Stress Mechanisms in Human Model Organism | Zendy

Zeynep Atasayar Ünver | Zendy; Meliha Koldemir Gündüz | Zendy; Figen Esin Kayhan | Zendy; Güllü Kaymak | Zendy; Ulgen ZENGİN | Zendy; Penbe Çağatay | Zendy; Belgin Süsleyici Duman | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

The Effects of Peroxiredoxin 6 Gene rs41055489 Variation on Oxidative Stress Mechanisms in Human Model Organism

Author(s) -

Zeynep Atasayar Ünver,

Meliha Koldemir Gündüz,

Figen Esin Kayhan,

Güllü Kaymak,

Ulgen ZENGİN,

Penbe Çağatay,

Belgin Süsleyici Duman

Publication year - 2015

Publication title -

bezmialem science

Language(s) - English

Resource type - Journals

ISSN - 2148-2373

DOI - 10.14235/bs.2015.542

Subject(s) - organism , oxidative stress , peroxiredoxin , medicine , model organism , gene , genetics , biology , biochemistry , endocrinology , peroxidase , enzyme

Objective: Peroxiredoxins (Prx) belong to peroxidase type enzyme group which reduce redox active cysteine residues. The aim of this study was to determine the allele frequencies of Prx 6 gene rs41055489 polymorphism in zebrafish and in which extent may improve protective measures against oxidative stress indicators. Methods: The Prx6 gene rs41055489 genotypes were determined with qPCR method in zebrafish exposed to different doses of heavy metals. Additionally, the glutathion (GSH), malondialdehide (MDA) and catalase (CAT) levels were measured. Results: The Prx6 gene rs41055489 genotype frequencies were determined respectively as 97.7% for homozygous wild type (A/A), 2.3% for heterozygous (A/C) in group. The polymorphic genotype (C/C) was not detected in our study group. Conclusion: Prx6 rs41055489 heterozygous gene polymorphism have been observed to inhibit defence mechanisms.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research