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3 ACKNOWLEDGEMENTS 4 LIST OF ORIGINAL ARTICLES 5 AUTHOR’S CONTRIBUTION 5 INTRODUCTION 7 BACKGROUND 7 The lifecycle of Plasmodium vivax 9 Anopheles vectors of northern malaria 12 Study area, material and methods 13 MAIN RESULTS 14 Plasmodium vivax and climate 15 The advantage of a relapse triggered by mosquitoes 16 The decline and extinction of Plasmodium vivax in a metapopulation dynamic concept 18 CONCLUSIONS 22 REFERENCES 23

The decline of northern malaria and population dynamics of Plasmodium vivax