Comparison of Urine and Plasma Biomarker Concentrations Measured by Aptamer-Based versus Immunoassay Methods in Cardiac Surgery Patients | Zendy

Lidiya Kukova | Zendy; Sherry G. Mansour | Zendy; Steven G. Coca | Zendy; Christina A. de Fontnouvelle | Zendy; Heather ThiessenPhilbrook | Zendy; Michael G. Shlipak | Zendy; Joe M El-Khoury | Zendy; Chirag R. Parikh | Zendy

Open Access

Comparison of Urine and Plasma Biomarker Concentrations Measured by Aptamer-Based versus Immunoassay Methods in Cardiac Surgery Patients

Author(s) -

Lidiya Kukova,

Sherry G. Mansour,

Steven G. Coca,

Christina A. de Fontnouvelle,

Heather ThiessenPhilbrook,

Michael G. Shlipak,

Joe M El-Khoury,

Chirag R. Parikh

Publication year - 2019

Publication title -

the journal of applied laboratory medicine

Language(s) - English

Resource type - Journals

eISSN - 2576-9456

pISSN - 2475-7241

DOI - 10.1373/jalm.2018.028621

Subject(s) - aptamer , immunoassay , urine , biomarker , medicine , plasma concentration , chromatography , urology , chemistry , biology , microbiology and biotechnology , antibody , immunology , biochemistry

Protein detection assays are invaluable tools in the field of biomarker discovery. However, only immunoassays are widely used and can measure 10-20 analytes per biosample. The novel SOMAmer-based assay uses nucleotide aptamer technology to measure over 1300 analytes per biosample. We compared the SOMAmer-based platform to traditional approaches to quantify analytes in a clinical setting with paired samples before and after cardiac surgery.

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