A Dilution Method to Mitigate Biotin Interference in Cardiac Troponin T Testing | Zendy

Nicholas Bevins | Zendy; Jacqueline A. Hubbard | Zendy; Robert L. Fitzgerald | Zendy; Michael J. Kelner | Zendy

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A Dilution Method to Mitigate Biotin Interference in Cardiac Troponin T Testing

Author(s) -

Nicholas Bevins,

Jacqueline A. Hubbard,

Robert L. Fitzgerald,

Michael J. Kelner

Publication year - 2019

Publication title -

the journal of applied laboratory medicine

Language(s) - English

Resource type - Journals

eISSN - 2576-9456

pISSN - 2475-7241

DOI - 10.1373/jalm.2018.028589

Subject(s) - biotin , dilution , troponin complex , streptavidin , chemistry , immunoassay , analyte , chromatography , medicine , troponin , myocardial infarction , biochemistry , antibody , immunology , physics , thermodynamics

Oral biotin supplementation is known to interfere with biotin-streptavidin-based immunoassays, including Roche's fifth-generation cardiac troponin T (cTnT) assay, which plays a critical role in the diagnosis of myocardial infarction (MI). The utility of dilution, a quick and easy method to detect and remove interferences, has not been published for biotin interference.

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