Transition of Methotrexate Polyglutamate Drug Monitoring Assay from Venipuncture to Capillary Blood-Based Collection Method in Rheumatic Diseases | Zendy

Kelley Brady | Zendy; Ying Qu | Zendy; Deborah Stimson | Zendy; Robert Apilado | Zendy; Roberta Vezza Alexander | Zendy; Smitha Reddy | Zendy; Puja Chitkara | Zendy; John Conklin | Zendy; Tyler O’Malley | Zendy; Claudia Ibarra | Zendy; Thierry Dervieux | Zendy

Open Access

Transition of Methotrexate Polyglutamate Drug Monitoring Assay from Venipuncture to Capillary Blood-Based Collection Method in Rheumatic Diseases

Author(s) -

Kelley Brady,

Ying Qu,

Deborah Stimson,

Robert Apilado,

Roberta Vezza Alexander,

Smitha Reddy,

Puja Chitkara,

John Conklin,

Tyler O’Malley,

Claudia Ibarra,

Thierry Dervieux

Publication year - 2019

Publication title -

the journal of applied laboratory medicine

Language(s) - English

Resource type - Journals

eISSN - 2576-9456

pISSN - 2475-7241

DOI - 10.1373/jalm.2018.027730

Subject(s) - fingerstick , venipuncture , medicine , venous blood , whole blood , methotrexate , therapeutic drug monitoring , phlebotomy , pharmacology , pharmacokinetics , anesthesia , endocrinology , diabetes mellitus

Methotrexate (MTX) polyglutamate (MTXPG 3 ) levels from isolated red blood cells (RBCs) collected by venipuncture have clinical utility in guiding MTX dosing for patients with rheumatoid arthritis (RA). Our objective was to transition this RBC-based therapeutic drug monitoring (TDM) assay to dried capillary blood collected by fingerstick.

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