A Rapid High-Performance LC-MS/MS Method for Therapeutic Drug Monitoring of Voriconazole, Posaconazole, Fluconazole, and Itraconazole in Human Serum | Zendy

Yi Xiao | Zendy; Yan-Kang Xu | Zendy; Paul K. Pattengale | Zendy; Maurice R.G. O’Gorman | Zendy; Xiaowei Fu | Zendy

Open Access

A Rapid High-Performance LC-MS/MS Method for Therapeutic Drug Monitoring of Voriconazole, Posaconazole, Fluconazole, and Itraconazole in Human Serum

Author(s) -

Yi Xiao,

Yan-Kang Xu,

Paul K. Pattengale,

Maurice R.G. O’Gorman,

Xiaowei Fu

Publication year - 2017

Publication title -

the journal of applied laboratory medicine

Language(s) - English

Resource type - Journals

eISSN - 2576-9456

pISSN - 2475-7241

DOI - 10.1373/jalm.2016.022756

Subject(s) - posaconazole , therapeutic drug monitoring , itraconazole , voriconazole , fluconazole , chromatography , protein precipitation , chemistry , pharmacology , high performance liquid chromatography , antifungal , drug , medicine , dermatology

To achieve therapeutic efficacy and prevent toxicity simultaneously, therapeutic drug monitoring has been increasingly adopted for antifungal agents with narrow therapeutic indexes. We herein report the development and validation of an accurate, simple, fast, and cost-effective clinical test with high-performance LC-MS/MS to simultaneously quantify voriconazole, posaconazole, fluconazole, and itraconazole in human serum.

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