α-Methyldopa Interference in Urinary Normetanephrine Measurement by LC-MS/MS? | Zendy

Johannes M. van den Ouweland | Zendy; M.J.T.M. Mol | Zendy; Leon Tax | Zendy; Twan Beijers | Zendy; Henny van Daal | Zendy

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α-Methyldopa Interference in Urinary Normetanephrine Measurement by LC-MS/MS?

Author(s) -

Johannes M. van den Ouweland,

M.J.T.M. Mol,

Leon Tax,

Twan Beijers,

Henny van Daal

Publication year - 2016

Publication title -

the journal of applied laboratory medicine

Language(s) - English

Resource type - Journals

eISSN - 2576-9456

pISSN - 2475-7241

DOI - 10.1373/jalm.2016.020925

Subject(s) - normetanephrine , interference (communication) , methyldopa , urinary system , chemistry , medicine , computer science , blood pressure , telecommunications , channel (broadcasting)

To the Editor:In general, LC-MS/MS is thought to be more selective and less susceptible to analytical interferences when compared to HPLC. In urinary or plasma metanephrine analysis for diagnoses of pheochromocytoma, false-positive results could arise either from direct interference with the analytical method or pharmacological effects on the disposition of catecholamines (1).Here, we present a case of analytical interference from α-methyldopa (AMD)1 (Aldomet) in our LC-MS/MS method for urinary metanephrine analysis. A 36-year-old woman was referred to our hospital for diagnostic work-up of her hypertension. She had been successfully treated with AMD for hypertension during pregnancy. Postpartum, after initial normalization, her blood pressure increased despite …

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