Performance of the MasSpec Pen for Rapid Diagnosis of Ovarian Cancer | Zendy

Marta Sans | Zendy; Jialing Zhang | Zendy; John Q. Lin | Zendy; Clara L. Feider | Zendy; Noah Giese | Zendy; Michael Breen | Zendy; Katherine Sebastian | Zendy; Jun S. Liu | Zendy; Anil K. Sood | Zendy; Lívia S. Eberlin | Zendy

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Performance of the MasSpec Pen for Rapid Diagnosis of Ovarian Cancer

Author(s) -

Marta Sans,

Jialing Zhang,

John Q. Lin,

Clara L. Feider,

Noah Giese,

Michael Breen,

Katherine Sebastian,

Jun S. Liu,

Anil K. Sood,

Lívia S. Eberlin

Publication year - 2019

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2018.299289

Subject(s) - ovarian cancer , serous fluid , fallopian tube , medicine , orbitrap , serous ovarian cancer , cancer , ovarian carcinoma , serous carcinoma , oncology , pathology , mass spectrometry , chemistry , surgery , chromatography

Accurate tissue diagnosis during ovarian cancer surgery is critical to maximize cancer excision and define treatment options. Yet, current methods for intraoperative tissue evaluation can be time intensive and subjective. We have developed a handheld and biocompatible device coupled to a mass spectrometer, the MasSpec Pen, which uses a discrete water droplet for molecular extraction and rapid tissue diagnosis. Here we evaluated the performance of this technology for ovarian cancer diagnosis across different sample sets, tissue types, and mass spectrometry systems.

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