Validation of a Metabolite Panel for a More Accurate Estimation of Glomerular Filtration Rate Using Quantitative LC-MS/MS | Zendy

Tiffany A. Freed | Zendy; Josef Coresh | Zendy; Lesley A. Inker | Zendy; Douglas R. Toal | Zendy; Régis Périchon | Zendy; Jingsha Chen | Zendy; Kelli D. Goodman | Zendy; Qibo Zhang | Zendy; Jessie K. Conner | Zendy; Deirdre M. Hauser | Zendy; Kate E.T. Vroom | Zendy; Maria L Oyaski | Zendy; Jacob Wulff | Zendy; Guðný Eiríksdóttir | Zendy; Vilmundur Guðnason | Zendy; Vicente E. Torres | Zendy; Lisa A. Ford | Zendy; Andrew S. Levey | Zendy

Open Access

Validation of a Metabolite Panel for a More Accurate Estimation of Glomerular Filtration Rate Using Quantitative LC-MS/MS

Author(s) -

Tiffany A. Freed,

Josef Coresh,

Lesley A. Inker,

Douglas R. Toal,

Régis Périchon,

Jingsha Chen,

Kelli D. Goodman,

Qibo Zhang,

Jessie K. Conner,

Deirdre M. Hauser,

Kate E.T. Vroom,

Maria L Oyaski,

Jacob Wulff,

Guðný Eiríksdóttir,

Vilmundur Guðnason,

Vicente E. Torres,

Lisa A. Ford,

Andrew S. Levey

Publication year - 2019

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2018.288092

Subject(s) - cystatin c , analyte , creatinine , renal function , chromatography , chemistry , metabolite , urology , medicine , biochemistry

Clinical practice guidelines recommend estimation of glomerular filtration rate (eGFR) using validated equations based on serum creatinine (eGFRcr), cystatin C (eGFRcys), or both (eGFRcr-cys). However, when compared with the measured GFR (mGFR), only eGFRcr-cys meets recommended performance standards. Our goal was to develop a more accurate eGFR method using a panel of metabolites without creatinine, cystatin C, or demographic variables.

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