Open AccessFull-Size Cardiac Troponin I and Its Proteolytic Fragments in Blood of Patients with Acute Myocardial Infarction: Antibody Selection for Assay Development
Author(s) -
Ivan A. Katrukha,
Alexander E Kogan,
Alexandra V Vylegzhanina,
Alexey V. Kharitonov,
Natalia N Tamm,
Vladimir Vladimirovich Filatov,
A. Bereznikova,
Ekaterina V Koshkina,
Alexey G Katrukha
Publication year - 2018
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2017.286211
Subject(s) - troponin i , epitope , myocardial infarction , medicine , antibody , monoclonal antibody , troponin , cardiology , microbiology and biotechnology , immunology , biology
In the blood of patients with acute myocardial infarction (AMI), cardiac troponin I (cTnI) presents as an intact molecule with a repertoire of proteolytic fragments. The degradation of cTnI might negatively influence its precise immunodetection. In this study we identified cTnI fragments and calculated their ratio in the blood of patients at different times after AMI to discriminate the most stable part(s) of cTnI.
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