Genetic Evidence That Carbohydrate-Stimulated Insulin Secretion Leads to Obesity | Zendy

Christina M. Astley | Zendy; Jennifer N. Todd | Zendy; Rany M. Salem | Zendy; Sailaja Vedantam | Zendy; Cara B. Ebbeling | Zendy; Paul L. Huang | Zendy; David S. Ludwig | Zendy; Joel N. Hirschhorn | Zendy; José C. Florez | Zendy

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Genetic Evidence That Carbohydrate-Stimulated Insulin Secretion Leads to Obesity

Author(s) -

Christina M. Astley,

Jennifer N. Todd,

Rany M. Salem,

Sailaja Vedantam,

Cara B. Ebbeling,

Paul L. Huang,

David S. Ludwig,

Joel N. Hirschhorn,

José C. Florez

Publication year - 2018

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2017.280727

Subject(s) - mendelian randomization , insulin , endocrinology , medicine , insulin resistance , hyperinsulinemia , obesity , body mass index , biology , genetics , genotype , genetic variants , gene

A fundamental precept of the carbohydrate-insulin model of obesity is that insulin secretion drives weight gain. However, fasting hyperinsulinemia can also be driven by obesity-induced insulin resistance. We used genetic variation to isolate and estimate the potentially causal effect of insulin secretion on body weight.

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