Rapid, Secure Drug Testing Using Fingerprint Development and Paper Spray Mass Spectrometry | Zendy

Catia Costa | Zendy; R.P. Webb | Zendy; Vladimir Palitsin | Zendy; Mahado Ismail | Zendy; Marcel de Puit | Zendy; Samuel F. Atkinson | Zendy; Melanie J. Bailey | Zendy

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Rapid, Secure Drug Testing Using Fingerprint Development and Paper Spray Mass Spectrometry

Author(s) -

Catia Costa,

R.P. Webb,

Vladimir Palitsin,

Mahado Ismail,

Marcel de Puit,

Samuel F. Atkinson,

Melanie J. Bailey

Publication year - 2017

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2017.275578

Subject(s) - benzoylecgonine , chromatography , fingerprint (computing) , mass spectrometry , chemistry , drug detection , matrix (chemical analysis) , analytical chemistry (journal) , computer science , urine , artificial intelligence , biochemistry

BACKGROUND: Paper spray mass spectrometry6 is a technique\udthat has recently emerged and has shown excellent\udanalytical sensitivity to a number of drugs in blood. As an\udalternative to blood, fingerprints have been shown to\udprovide a noninvasive and traceable sampling matrix.\udOur goal was to validate the use of fingerprint samples to\uddetect cocaine use.

\ud

METHODS: Samples were collected on triangular pieces\ud(168 mm2) of washed Whatman Grade I chromatography\udpaper. Following application of internal standard,\udspray solvent and a voltage were applied to the paper\udbefore mass spectrometry detection. A fingerprint visualization\udstep was incorporated into the analysis procedure\udby addition of silver nitrate solution and exposing the\udsample to ultraviolet light.

\ud

RESULTS: Limits of detection for cocaine, benzoylecgonine,\udand methylecgonine were 1, 2, and 31 ng/mL respectively,\udwith relative standard deviations of less than 33%. No\udmatrix effects were observed. Analysis of 239 fingerprint\udsamples yielded a 99% true-positive rate and a 2.5%\udfalse-positive rate, based on the detection of cocaine,\udbenzoylecgonine, or methylecgonine with use of a single\udfingerprint.

\ud

CONCLUSIONS: The method offers a qualitative and noninvasive\udscreening test for cocaine use. The analysis\udmethod developed is rapid (4 min/sample) and requires\udno sample preparation.

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