Clinical Evaluation of a Blood Assay to Diagnose Paucibacillary Tuberculosis via Bacterial Antigens | Zendy

Chang Liu | Zendy; Christopher J. Lyon | Zendy; Yang Bu | Zendy; Zaian Deng | Zendy; Elisabetta Walters | Zendy; Yan Li | Zendy; Liqun Zhang | Zendy; Anneke C. Hesseling | Zendy; Edward A. Graviss | Zendy; Ye Hu | Zendy

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Clinical Evaluation of a Blood Assay to Diagnose Paucibacillary Tuberculosis via Bacterial Antigens

Author(s) -

Chang Liu,

Christopher J. Lyon,

Yang Bu,

Zaian Deng,

Elisabetta Walters,

Yan Li,

Liqun Zhang,

Anneke C. Hesseling,

Edward A. Graviss,

Ye Hu

Publication year - 2018

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2017.273698

Subject(s) - mycobacterium tuberculosis , tuberculosis , antigen , medicine , blood culture , tuberculosis diagnosis , mycobacterium , disease , immunology , bacilli , virology , microbiology and biotechnology , biology , bacteria , pathology , antibiotics , genetics

The diagnosis of active tuberculosis (TB) cases primarily relies on methods that detect Mycobacterium tuberculosis ( Mtb ) bacilli or their DNA in patient samples (e.g., mycobacterial culture and Xpert MTB/RIF assays), but these tests have low clinical sensitivity for patients with paucibacillary TB disease. Our goal was to evaluate the clinical performance of a newly developed assay that can rapidly diagnose active TB cases by direct detection of Mtb -derived antigens in patients' blood samples.

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