Harmonization of Serum Thyroid-Stimulating Hormone Measurements Paves the Way for the Adoption of a More Uniform Reference Interval | Zendy

Linda M. Thienpont | Zendy; Katleen Van Uytfanghe | Zendy; Linde A.C. De Grande | Zendy; Dries Reynders | Zendy; Barnali Das | Zendy; James D. Faix | Zendy; Finlay MacKenzie | Zendy; Brigitte Decallonne | Zendy; Akira Hishinuma | Zendy; Bruno Lapauw | Zendy; Paul Taelman | Zendy; Paul Van Crombrugge | Zendy; Annick Van den Bruel | Zendy; Brigitte Velkeniers | Zendy; Paul F. Williams | Zendy

Open Access

Harmonization of Serum Thyroid-Stimulating Hormone Measurements Paves the Way for the Adoption of a More Uniform Reference Interval

Author(s) -

Linda M. Thienpont,

Katleen Van Uytfanghe,

Linde A.C. De Grande,

Dries Reynders,

Barnali Das,

James D. Faix,

Finlay MacKenzie,

Brigitte Decallonne,

Akira Hishinuma,

Bruno Lapauw,

Paul Taelman,

Paul Van Crombrugge,

Annick Van den Bruel,

Brigitte Velkeniers,

Paul F. Williams

Publication year - 2017

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2016.269456

Subject(s) - confidence interval , harmonization , calibration , percentile , statistics , free thyroxine , medicine , thyroid function , mathematics , thyroid stimulating hormone , standardization , hormone , computer science , physics , acoustics , operating system

The IFCC Committee for Standardization of Thyroid Function Tests developed a global harmonization approach for thyroid-stimulating hormone measurements. It is based on a multiassay method comparison study with clinical serum samples and target setting with a robust factor analysis method. Here we describe the Phase IV method comparison and reference interval (RI) studies conducted with the objective to recalibrate the participating assays and demonstrate the proof-of-concept.

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