Rapid RHD Zygosity Determination Using Digital PCR | Zendy

Kelly A. Sillence | Zendy; Amr J Halawani | Zendy; Wajnat A. Tounsi | Zendy; Kirsty A Clarke | Zendy; Michele Kiernan | Zendy; Tracey E. Madgett | Zendy; Neil D. Avent | Zendy

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Rapid RHD Zygosity Determination Using Digital PCR

Author(s) -

Kelly A. Sillence,

Amr J Halawani,

Wajnat A. Tounsi,

Kirsty A Clarke,

Michele Kiernan,

Tracey E. Madgett,

Neil D. Avent

Publication year - 2017

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2016.268698

Subject(s) - zygosity , genotyping , genotype , biology , concordance , sanger sequencing , digital polymerase chain reaction , multiplex , genetics , multiplex polymerase chain reaction , polymerase chain reaction , dna sequencing , gene

Paternal zygosity testing is used for determining homo- or hemizygosity of RHD in pregnancies that are at a risk of hemolytic disease of the fetus and newborn. At present, this is achieved by using real-time PCR or the Rhesus box PCR, which can be difficult to interpret and unreliable, particularly for black African populations.

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