Specificity of B-Type Natriuretic Peptide Assays: Cross-Reactivity with Different BNP, NT-proBNP, and proBNP Peptides | Zendy

Amy K. Saenger | Zendy; Olaia RodríguezFraga | Zendy; Ranka Ler | Zendy; Jordi OrdóñezLlanos | Zendy; Allan S. Jaffe | Zendy; Jens P. Goetze | Zendy; Fred S. Apple | Zendy

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Specificity of B-Type Natriuretic Peptide Assays: Cross-Reactivity with Different BNP, NT-proBNP, and proBNP Peptides

Author(s) -

Amy K. Saenger,

Olaia RodríguezFraga,

Ranka Ler,

Jordi OrdóñezLlanos,

Allan S. Jaffe,

Jens P. Goetze,

Fred S. Apple

Publication year - 2016

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2016.263749

Subject(s) - natriuretic peptide , medicine , brain natriuretic peptide , peptide , cross reactivity , npr2 , chemistry , endocrinology , antibody , cross reactions , biochemistry , immunology , heart failure

B-type natriuretic peptides (BNPs) are used clinically to diagnose and monitor heart failure and are present in the circulation as multiple proBNP-derived fragments. We investigated the specificity of BNP immunoassays with glycosylated and nonglycosylated BNP, N-terminal proBNP (NT-proBNP), and proBNP peptides to probe the cross-reactivity of each assay.

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