Next Generation Sequencing of Circulating Cell-Free DNA for Evaluating Mutations and Gene Amplification in Metastatic Breast Cancer | Zendy

Karen Page | Zendy; David S. Guttery | Zendy; Daniel Fernández-García | Zendy; Allison Hills | Zendy; Robert Hastings | Zendy; Jinli Luo | Zendy; Kate Goddard | Zendy; Vedia Shahin | Zendy; Laura Woodley-Barker | Zendy; Brenda Rosales | Zendy; R. Charles Coombes | Zendy; Justin Stebbing | Zendy; Jacqui Shaw | Zendy

Open Access

Next Generation Sequencing of Circulating Cell-Free DNA for Evaluating Mutations and Gene Amplification in Metastatic Breast Cancer

Author(s) -

Karen Page,

David S. Guttery,

Daniel Fernández-García,

Allison Hills,

Robert Hastings,

Jinli Luo,

Kate Goddard,

Vedia Shahin,

Laura Woodley-Barker,

Brenda Rosales,

R. Charles Coombes,

Justin Stebbing,

Jacqui Shaw

Publication year - 2016

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2016.261834

Subject(s) - amplicon , breast cancer , metastatic breast cancer , cold pcr , digital polymerase chain reaction , biology , cancer research , somatic evolution in cancer , gene duplication , cancer , somatic cell , cell free fetal dna , mutation , copy number variation , estrogen receptor , germline mutation , gene , point mutation , polymerase chain reaction , genetics , genome , pregnancy , fetus , prenatal diagnosis

Breast cancer tissues are heterogeneous and show diverse somatic mutations and somatic copy number alterations (CNAs). We used a novel targeted next generation sequencing (NGS) panel to examine cell-free DNA (cfDNA) to detect somatic mutations and gene amplification in women with metastatic breast cancer (MBC).

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