Anti–Cardiac Troponin Autoantibodies Are Specific to the Conformational Epitopes Formed by Cardiac Troponin I and Troponin T in the Ternary Troponin Complex | Zendy

Alexandra V Vylegzhanina | Zendy; Alexander E Kogan | Zendy; Ivan A. Katrukha | Zendy; О. В. Антипова | Zendy; Andrey N. Kara | Zendy; A. Bereznikova | Zendy; Ekaterina V Koshkina | Zendy; Alexey G Katrukha | Zendy

Open Access

Anti–Cardiac Troponin Autoantibodies Are Specific to the Conformational Epitopes Formed by Cardiac Troponin I and Troponin T in the Ternary Troponin Complex

Author(s) -

Alexandra V Vylegzhanina,

Alexander E Kogan,

Ivan A. Katrukha,

О. В. Антипова,

Andrey N. Kara,

A. Bereznikova,

Ekaterina V Koshkina,

Alexey G Katrukha

Publication year - 2016

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2016.261602

Subject(s) - troponin , cardiology , troponin t , epitope , medicine , autoantibody , troponin complex , troponin i , antibody , myocardial infarction , immunology

Autoantibodies to cardiac troponins (TnAAbs) could negatively affect cardiac troponin I (cTnI) measurements by TnAAbs-sensitive immunoassays. We investigated the epitope specificity of TnAAbs and its influence on cTnI immunodetection in patients with acute myocardial infarction (AMI).

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