Open AccessDirect Comparison of Metastasis-Related miRNAs Expression Levels in Circulating Tumor Cells, Corresponding Plasma, and Primary Tumors of Breast Cancer Patients
Author(s) -
Athina Markou,
Martha Zavridou,
Ioanna Sourvinou,
George M. Yousef,
Sofia Kounelis,
Nikos Malamos,
Vasilis Georgoulias,
Evi Lianidou
Publication year - 2016
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2015.253716
Subject(s) - circulating tumor cell , microrna , breast cancer , metastasis , primary tumor , cancer , metastatic breast cancer , medicine , pathology , cancer research , oncology , biology , gene , biochemistry
Circulating tumor cells (CTCs) and microRNAs (miRNAs) are important in liquid biopsies in which peripheral blood is used to characterize the evolution of solid tumors. We evaluated the expression levels of miR-21, miR-146a, miR-200c, and miR-210 in CTCs of breast cancer patients with verified metastasis and compared their expression levels in corresponding plasma and primary tumors.
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