Open AccessEarly-Phase Studies of Biomarkers: What Target Sensitivity and Specificity Values Might Confer Clinical Utility?
Author(s) -
Margaret S. Pepe,
Holly Janes,
Christopher I. Li,
Patrick M. Bossuyt,
Ziding Feng,
Jørgen Hilden
Publication year - 2016
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2015.252163
Subject(s) - sensitivity (control systems) , medicine , engineering , electronic engineering
Many cancer biomarker research studies seek to develop markers that can accurately detect or predict future onset of disease. To design and evaluate these studies, one must specify the levels of accuracy sought. However, justified target levels are rarely available.
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