Automated Multiplex LC-MS/MS Assay for Quantifying Serum Apolipoproteins A-I, B, C-I, C-II, C-III, and E with Qualitative Apolipoprotein E Phenotyping | Zendy

Irene van den Broek | Zendy; Fred P.H.T.M. Romijn | Zendy; Jan Nouta | Zendy; Arnoud van der Laarse | Zendy; Jan W. Drijfhout | Zendy; Nico P.M. Smit | Zendy; Yuri E. M. van der Burgt | Zendy; Christa M. Cobbaert | Zendy

Open Access

Automated Multiplex LC-MS/MS Assay for Quantifying Serum Apolipoproteins A-I, B, C-I, C-II, C-III, and E with Qualitative Apolipoprotein E Phenotyping

Author(s) -

Irene van den Broek,

Fred P.H.T.M. Romijn,

Jan Nouta,

Arnoud van der Laarse,

Jan W. Drijfhout,

Nico P.M. Smit,

Yuri E. M. van der Burgt,

Christa M. Cobbaert

Publication year - 2015

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2015.246702

Subject(s) - apolipoprotein b , multiplex , chemistry , lipoprotein , chromatography , hypertriglyceridemia , microbiology and biotechnology , triglyceride , cholesterol , biology , biochemistry , bioinformatics

Direct and calculated measures of lipoprotein fractions for cardiovascular risk assessment suffer from analytical inaccuracy in certain dyslipidemic and pathological states, most commonly hypertriglyceridemia. LC-MS/MS has proven suitable for multiplexed quantification and phenotyping of apolipoproteins. We developed and provisionally validated an automated assay for quantification of apolipoprotein (apo) A-I, B, C-I, C-II, C-III, and E and simultaneous qualitative assessment of apoE phenotypes.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research