Open AccessMultiplexed Quantification of Proglucagon-Derived Peptides by Immunoaffinity Enrichment and Tandem Mass Spectrometry after a Meal Tolerance Test
Author(s) -
Anita Y. H. Lee,
Derek L Chappell,
Monika Bąk,
Michael Judo,
Linda Liang,
Tatyana Churakova,
Gulesi Ayanoglu,
José CastroPerez,
Haihong Zhou,
Stephen F. Previs,
Sandra C. Souza,
Michael E. Lassman,
Omar Laterza
Publication year - 2015
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2015.244251
Subject(s) - proglucagon , chemistry , glucagon , isotope dilution , chromatography , peptide , meal , tandem mass spectrometry , glucagon like peptide 1 , glucose homeostasis , endocrinology , medicine , mass spectrometry , hormone , biochemistry , biology , insulin , insulin resistance , food science , type 2 diabetes , diabetes mellitus
Proglucagon-derived peptides (PGDPs), which include glucagon-like peptide (GLP)-1, glucagon, and oxyntomodulin, are key regulators of glucose homeostasis and satiety. These peptide hormones are typically measured with immuno-based assays (e.g., ELISA, RIA), which often suffer from issues of selectivity.
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