Detecting Long-term Drift in Reagent Lots
Author(s) -
Jiakai Liu,
Chin Hon Tan,
Tze Ping Loh,
Tony Badrick
Publication year - 2015
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2015.242511
Subject(s) - reagent , statistics , term (time) , regression analysis , regression , consistency (knowledge bases) , linear regression , computer science , constant (computer programming) , statistical hypothesis testing , mathematics , artificial intelligence , chemistry , physics , programming language , quantum mechanics
Between-reagent lot verification is a routine laboratory exercise in which a set of samples is tested in parallel with an existing reagent lot and a candidate reagent lot (before the candidate lot is committed to test patient samples). The exercise aims to verify and maintain consistency in the analytical performance of a test. We examined the limitations of a routine between-reagent lot verification procedure in detecting long-term analytical drift and looked for a more sensitive alternative.
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