Continuous Age- and Sex-Adjusted Reference Intervals of Urinary Markers for Cerebral Creatine Deficiency Syndromes: A Novel Approach to the Definition of Reference Intervals | Zendy

Lars Mørkrid | Zendy; Alexander D. Rowe | Zendy; Katja Benedikte Prestø Elgstøen | Zendy; Jess Have Olesen | Zendy; George J. G. Ruijter | Zendy; Patricia Hall | Zendy; Silvia Tortorelli | Zendy; Andreas Schulze | Zendy; Lianna Kyriakopoulou | Zendy; Mirjam M. C. Wamelink | Zendy; Jiddeke M. van de Kamp | Zendy; Gajja S. Salomons | Zendy; Piero Rinaldo | Zendy

Open Access

Continuous Age- and Sex-Adjusted Reference Intervals of Urinary Markers for Cerebral Creatine Deficiency Syndromes: A Novel Approach to the Definition of Reference Intervals

Author(s) -

Lars Mørkrid,

Alexander D. Rowe,

Katja Benedikte Prestø Elgstøen,

Jess Have Olesen,

George J. G. Ruijter,

Patricia Hall,

Silvia Tortorelli,

Andreas Schulze,

Lianna Kyriakopoulou,

Mirjam M. C. Wamelink,

Jiddeke M. van de Kamp,

Gajja S. Salomons,

Piero Rinaldo

Publication year - 2015

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2014.235564

Subject(s) - percentile , confidence interval , statistics , medicine , linear regression , creatine , mathematics

Urinary concentrations of creatine and guanidinoacetic acid divided by creatinine are informative markers for cerebral creatine deficiency syndromes (CDSs). The renal excretion of these substances varies substantially with age and sex, challenging the sensitivity and specificity of postanalytical interpretation.

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