Brain Tumor Mutations Detected in Cerebral Spinal Fluid | Zendy

Wenying Pan | Zendy; Wei Gu | Zendy; Seema Nagpal | Zendy; Melanie Hayden Gephart | Zendy; Stephen R. Quake | Zendy

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Brain Tumor Mutations Detected in Cerebral Spinal Fluid

Author(s) -

Wenying Pan,

Wei Gu,

Seema Nagpal,

Melanie Hayden Gephart,

Stephen R. Quake

Publication year - 2015

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2014.235457

Subject(s) - liquid biopsy , digital polymerase chain reaction , brain tumor , cold pcr , medicine , circulating tumor cell , pathology , brain metastasis , primary tumor , mutation , cell free fetal dna , cerebrospinal fluid , somatic cell , brain biopsy , cancer , amplicon , metastasis , cancer research , biopsy , gene , biology , point mutation , polymerase chain reaction , genetics , pregnancy , fetus , prenatal diagnosis

Detecting tumor-derived cell-free DNA (cfDNA) in the blood of brain tumor patients is challenging, presumably owing to the blood-brain barrier. Cerebral spinal fluid (CSF) may serve as an alternative "liquid biopsy" of brain tumors by enabling measurement of circulating DNA within CSF to characterize tumor-specific mutations. Many aspects about the characteristics and detectability of tumor mutations in CSF remain undetermined.

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