Rapid Identification of Plasma DNA Samples with Increased ctDNA Levels by a Modified FAST-SeqS Approach | Zendy

Jelena Belic | Zendy; Marina Koch | Zendy; Peter Ulz | Zendy; Martina Auer | Zendy; Teresa Gerhalter | Zendy; Sumitra Mohan | Zendy; Katja Fischereder | Zendy; Edgar Petru | Zendy; Thomas Bauernhofer | Zendy; Jochen B. Geigl | Zendy; Michael R. Speicher | Zendy; Ellen Heitzer | Zendy

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Rapid Identification of Plasma DNA Samples with Increased ctDNA Levels by a Modified FAST-SeqS Approach

Author(s) -

Jelena Belic,

Marina Koch,

Peter Ulz,

Martina Auer,

Teresa Gerhalter,

Sumitra Mohan,

Katja Fischereder,

Edgar Petru,

Thomas Bauernhofer,

Jochen B. Geigl,

Michael R. Speicher,

Ellen Heitzer

Publication year - 2015

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2014.234286

Subject(s) - aneuploidy , dna , genome , biology , cell free fetal dna , computational biology , chromosome , genetics , microbiology and biotechnology , fetus , gene , prenatal diagnosis , pregnancy

Recent progress in the analysis of cell-free DNA fragments [cell-free circulating tumor DNA (ctDNA)] now allows monitoring of tumor genomes by noninvasive means. However, previous studies with plasma DNA from patients with cancer demonstrated highly variable allele frequencies of ctDNA. The comprehensive analysis of tumor genomes is greatly facilitated when plasma DNA has increased amounts of ctDNA. Therefore, a fast and cost-effective prescreening method to identify such plasma samples without previous knowledge about alterations in the respective tumor genome could assist in the selection of samples suitable for further extensive qualitative analysis.

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