Open AccessHigh-Sensitivity Cardiac Troponin T Concentrations below the Limit of Detection to Exclude Acute Myocardial Infarction: A Prospective Evaluation
Author(s) -
Richard Body,
Gillian Burrows,
Simon Carley,
Louise Cullen,
Martin Than,
Allan S. Jaffe,
Philip Lewis
Publication year - 2015
Publication title -
clinical chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2014.231530
Subject(s) - medicine , myocardial infarction , chest pain , troponin complex , cardiology , roche diagnostics , prospective cohort study , emergency department , troponin t , troponin , psychiatry
Initial reports suggest that concentrations of high-sensitivity cardiac troponin T (hs-cTnT) (Roche Diagnostics Elecsys(®)) below the limit of blank (LoB) (3 ng/L) or limit of detection (LoD) (5 ng/L) of the assay have almost 100% negative predictive value (NPV) for acute myocardial infarction (AMI), particularly among patients without electrocardiograph (ECG) evidence of ischemia. We aimed to prospectively validate those findings.
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