Liquid Chromatography High-Resolution TOF Analysis: Investigation of MSE for Broad-Spectrum Drug Screening | Zendy

Nandkishor S. Chindarkar | Zendy; Michael R Wakefield | Zendy; Judith Stone | Zendy; Robert L. Fitzgerald | Zendy

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Liquid Chromatography High-Resolution TOF Analysis: Investigation of MSE for Broad-Spectrum Drug Screening

Author(s) -

Nandkishor S. Chindarkar,

Michael R Wakefield,

Judith Stone,

Robert L. Fitzgerald

Publication year - 2014

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2014.222976

Subject(s) - false positive paradox , analyte , mass spectrometry , chromatography , chemistry , ion , mass spectrum , resolution (logic) , analytical chemistry (journal) , mass , high resolution , artificial intelligence , computer science , organic chemistry , remote sensing , geology

High-resolution mass spectrometry (HRMS) has the potential to supplement other drug screening platforms used in toxicology laboratories. HRMS offers high analytical specificity, which can be further enhanced by incorporating a fragment ion for each analyte. The ability to obtain precursor ions and fragment ions using elevated collision energies (MS(E)) can help improve the specificity of HRMS methods.

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