Use of Copy Number Deletion Polymorphisms to Assess DNA Chimerism | Zendy

Damien L. Bruno | Zendy; Devika Ganesamoorthy | Zendy; Natalie Thorne | Zendy; Ling Ling | Zendy; Melanie Bahlo | Zendy; Sue Forrest | Zendy; Marieke Veenendaal | Zendy; Marina Katerelos | Zendy; Alison Skene | Zendy; Frank Ierino | Zendy; David A. Power | Zendy; Howard R. Slater | Zendy

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Use of Copy Number Deletion Polymorphisms to Assess DNA Chimerism

Author(s) -

Damien L. Bruno,

Devika Ganesamoorthy,

Natalie Thorne,

Ling Ling,

Melanie Bahlo,

Sue Forrest,

Marieke Veenendaal,

Marina Katerelos,

Alison Skene,

Frank Ierino,

David A. Power,

Howard R. Slater

Publication year - 2014

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2013.216077

Subject(s) - biology , cell free fetal dna , digital polymerase chain reaction , genetics , dna , copy number variation , transplantation , genomic dna , dna sequencing , microbiology and biotechnology , polymerase chain reaction , prenatal diagnosis , gene , genome , fetus , medicine , pregnancy

We describe a novel approach that harnesses the ubiquity of copy number deletion polymorphisms in human genomes to definitively detect and quantify chimeric DNA in clinical samples. Unlike other molecular approaches to chimerism analysis, the copy number deletion (CND) method targets genomic loci (>50 base pairs in length) that are wholly absent from wild-type (i.e., self) background DNA sequences in a sex-independent manner.

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