Open AccessNoninvasive Micromarkers
Author(s) -
Janani Saikumar,
Krithika Ramachandran,
Vishal S. Vaidya
Publication year - 2014
Publication title -
clinical chemistry
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.705
H-Index - 218
eISSN - 1530-8561
pISSN - 0009-9147
DOI - 10.1373/clinchem.2013.216044
Subject(s) - microrna , computational biology , disease , biomarker , biomarker discovery , function (biology) , biology , biological fluids , bioinformatics , medicine , proteomics , pathology , genetics , chemistry , chromatography , gene
The recent revolutionary advances made in genome-wide sequencing technology have transformed biology and molecular diagnostics, allowing new sRNA (small RNA) classes to be discovered as potential disease-specific biological indicators. Cell-free microRNAs (miRNAs) have been shown to exist stably in a wide spectrum of body fluids and their expression profiles have been shown to reflect an assortment of physiological conditions, underscoring the utility of this new class of molecules to function as noninvasive biomarkers of disease.
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