Development of an Immunoassay for the Kidney-Specific Protein myo-Inositol Oxygenase, a Potential Biomarker of Acute Kidney Injury | Zendy

Joseph P. Gaut | Zendy; Dan L. Crimmins | Zendy; Matt F Ohlendorf | Zendy; Christina M. Lockwood | Zendy; Terry A. Griest | Zendy; Nancy Brada | Zendy; Masato Hoshi | Zendy; Bryan Sato | Zendy; Richard S. Hotchkiss | Zendy; Sanjay Jain | Zendy; Jack H. Ladenson | Zendy

Open Access

Development of an Immunoassay for the Kidney-Specific Protein myo-Inositol Oxygenase, a Potential Biomarker of Acute Kidney Injury

Author(s) -

Joseph P. Gaut,

Dan L. Crimmins,

Matt F Ohlendorf,

Christina M. Lockwood,

Terry A. Griest,

Nancy Brada,

Masato Hoshi,

Bryan Sato,

Richard S. Hotchkiss,

Sanjay Jain,

Jack H. Ladenson

Publication year - 2014

Publication title -

clinical chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.705

H-Index - 218

eISSN - 1530-8561

pISSN - 0009-9147

DOI - 10.1373/clinchem.2013.212993

Subject(s) - acute kidney injury , immunoassay , biomarker , creatinine , kidney , medicine , western blot , urology , recombinant dna , endocrinology , pathology , biology , antibody , immunology , biochemistry , gene

Acute kidney injury (AKI) affects 45% of critically ill patients, resulting in increased morbidity and mortality. The diagnostic standard, plasma creatinine, is nonspecific and may not increase until days after injury. There is significant need for a renal-specific AKI biomarker detectable early enough that there would be a potential window for therapeutic intervention. In this study, we sought to identify a renal-specific biomarker of AKI.

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